Can This DNA Hack Help You Stay Young Forever
I'm getting older, which would be fine ifit weren't for the fact that everything hurts and suddenly I need to nap all the time.Why body, whyé Hi everyone, Julian here for DNews. You mayhave heard the myth that the human body essentially replaces itself every 7 years. While that'snot strictly correct, I think I see the kernel of truth at the heart of this myth: most ofyour body's cells replace themselves over time. According to the Science Museum in London in the time it takes to say this sentence, 50 million of my roughly 75 trillion cellswill have died and been replaced. They do it at different rates though, with skin cellsdying off after two or three weeks while white
blood cells can live for an entire year. Soif most of you is hitting the refresh button all the time, why do our bodies still deteriorateé Scientists from the Salk Institute and theChinese Academy of Sciences think they're onto an answer. They were looking into theunderlying causes of Werner Syndrome, which causes premature aging and a whole host ofdisorders normally associated with people much older. About 1 in 20,000 people in theU.S. have it, and they are prone to early onset of cataracts, osteoporosis, and somecancers. Many of them die in their 40s or early 50s.
Werner syndrome is associated with a mutationin the WRN gene. For most people, the gene codes an enzyme that keeps DNA structuredsoundly. But with the mutation, the WRN protein isn't made properly and it affects the waythe DNA bundles itself. We're all familiar with the double helixshape of DNA, but there's more to it than that. If you were to stretch out the DNA fromjust one cell, it would be about 2 meters long. To be able to cram all this into justthe nucleus, DNA is packaged into chromatins. Euchromatin is looser, it looks like beadson a string, and this shape makes it easy for enzymes to access and code more proteins.Heterochromatin is more tightly bunched and
folded, which means the genes tucked in therearen't being expressed. That's why the vast majority of your cells have nearly identicalDNA but they do very different jobs. Heterochromatin is folded differently from one type of cellto another, and the way it's bunched determines what genes are switched off. This way thecell saves energy and only does the job it's specified for. The researchers mimicked Werner syndrome bydeleting the WRN gene in healthy stem cells and letting the DNA carry on as usual. Withoutthe WRN protein to interact with the markers on the heterochromatin called epigenetic tags,the scientists found the heterochromatin started
bunching differently and the cells aged faster.This could be expanded beyond just people with Werner syndrome: it's possible theheterochromatin shapes change over our lifetimes after being wound into chromosomes and replicatedand divided over and over. Maybe this is what makes our DNA express itself differently andcauses our slow decline into brittle old meat sacks. And if that's the case, maybe it'spossible to stop or even reverse the aging process, provided we can also solve a fewother problems father time throws at your DNA like your telomeres shortening. Telomeres are long tags at the end of chromosomesthat don't actually code any proteins. They
give the machinery that copies DNA a footholdbut they get a little shorter with every replication. When they're finally too short, the cellcan't divide anymore. There is an enzyme called a telomerase that adds to the endsof your chromosomes, but over your lifetime they can't keep up. There are a couple otherfactors in aging too, like oxidative stress, which is when free radicals damage DNA; andglycation, which is when glucose binds to DNA, proteins, or lipids and gums up the works.So if we sort out these other issues our DNA has to cope with as time passes, maybe it'spossible for me to be this young and beautiful forever. Ok, at least I'll be young.
No prison time in fatal DUI crash
LEARNED HIS FATE THIS MONTH. A JUDGE GAVE THIS MAN ROBERT HOWARD A 25YEAR SENTENCE. 16 WAPT'S ROSS ADAMS IS LIVE FROM WHERE THE CRASH HAPPENED WITH MORE.
THAT DEADLY CRASH HAPPENED MORE THAN TWO YEARS AGO HERE ON BULLARD STREET. AND NOW THE MAN CONVICTED IN THE DUI DEATH WILL NOT BE SPENDING ANY TIME IN
JAIL. ANOTHER RULING BY A HINDS COUNTY JUDGE RAISING EYEBROWS. DON'T SOUND LIKE JUSTICE TO ME. YOU GETTING AWAY PRACTICALLY WITH MURDER I THINK IT WOULD BE RIGHT
SERVE TIME. JUDGE BILL GOWAN LAST WEEK SENTENCED ROBERT LEE HOWARD TO 25 YEARS IN PRISON HOWARD PLED GUILTY ON TWO ARGARVATED DUI CHARGES THAT LEFT ONE MAN
DEAD. BUT THE JUDGE SUSPENDED THE ENTIRE SENTENCED. DID YOUR OFFICE JUST JAIL TIME YES WE. OFFERED EXTENDED JAIL TIME MUCH TIME IT WAS BETWEEN 15 AND 20 YEARS IS WHAT WE OFFERED.
HE GAVE HOWARD 20 YEARS PROBATION CITING HIS MEDICAL CONDITION. IT WAS NOTED THAT IT WOULD COST VERY COSTLY INCARCERATE PARTICULAR DEFENDANT THAT WAS ONE OF THE FACTORS THE COURT MENTIONED WHAT'S HIS
Dandys Day in Court Baby
hubbub of a crowd JUDGE 25A Order! We will now begin the trial ofthe defendant, Mister Dandy, also known as Space Dandy, who has been charged withthe murder of Guy Reginald. â™ª PROSECUTOR Ladies andGentlethings of the jury, at three a.m. Suburbia StandardTime on the twelfth day
of the thirteenth month, a heinous crime wascommitted with a baseball. In a fit of brutality, a nefarious monstermurdered Guy Reginald. And that monster is Space Dandy. Well. That's all for now. JUDGE 25A How will you pleadin this case, Mister Dandyé Seems he's exercisinghis right to remain silent.
PROSECUTOR The victim wasa Lumetian named Guy Reginald. Now, when he was discovered,his skull exhibited a circular depression matchingthat of an ordinary baseball a baseball that wassmashed into his head, causing immediate death! PROSECUTOR After hearing ascream, the victim's wife, Rose, rushed into the room to find herhusband lying dead on the floor. Standing next to the body
was the defendant, Mister Dandy. A baseball andmask were also found. We believe the defendanthid his face with the mask, snuck into the room, and used that ball tocommit this ghastly murder. LAWYER Objection! The defendant claimshe's an alien hunter. He was there tocatch Mister Reginald,
not kill the poor creature. We'll see.Now, then. Let's hear the prosecution'scase and star witness. PROSECUTOR Ms. Scarlet,do you know the defendant, Mister Dandyé Yes. He's a regular at thealien registration center. PROSECUTOR And would youplease inform the court
of his track recordwith registered aliensé Well, I supposeit's abnormal for him to bring in anythingvery impressive. PROSECUTOR Then I supposethe court can suppose he had no proven track record. The defendant,with no credentials or achievements, was desperate. So desperate, he'd useany means necessary